New paramagnetic contrast agents improve treatments

Alex Rovira, Head of the Department of Neuroradiology at Vall d’Hebron University Hospital and Head of Publications at the Spanish Society of Medical Radiology (SERAM).

when you talk about X-ray by MRIthe concept of quality is directly related to improving diagnosis and treatment, especially in areas such as Neuroradiology. To get the best result, the equipment used is very important, but other elements such as the contrast medium, in constant development, are also essential. Within this field, the Paramagnetic Contrast Modeswhich represents an important step forward in terms of ensuring prognosis for patients with structural changes affecting the nervous system.

In order to address developments in this field, and coinciding with the celebration of 36th National Congress of the Spanish Society of Medical Radiology (CIRAM)And the medical writing Call Alex Rovira, Head of the Department of Neuroradiology at Vall d’Hebron University Hospital (Barcelona) Responsible for the publications of the Spanish Society of Medical Radiology (Ceram). In the interview, sponsored by Bayer, the specialist describes a high-quality image as “essential” and looks to a future marked by the development of New contrasts with gadolinium They provide greater “relaxation” which, in addition to image quality, leads to patient safety.

What is the importance of image quality in neuroradiology in terms of diagnosis and treatment of patients?

In general, the quality of files Radiological studies It is necessary to do Accurate diagnosis. In this sense, there is Various recommendations which indicate how to obtain these studies in specific clinical cases have the dual objective of obtaining them with appropriate and homogeneous technology, and their use Reasonable checking times.

All this is necessary not only for a correct interpretation of studies, but also for adequate comparative analyzes of radiological studies obtained at different times and in different centers.


“MRI is the most important imaging technique in neuroscience both in clinical practice and in research.”



What are the main diseases that are found thanks to techniques such as MRI in these patients?

The Magnetic Resonance (MRI) is an image-based diagnostic technology that began to be used in clinical practice in the early 1980s and, eventually, towards the end of that decade. That was in the early ’90s for real Explosion in the use of MRnot only as a diagnostic method that is simply complementary to other more established methods (conventional radiology, computed tomography, intra-arterial angiography), but also First Choice Technology In many pathological processes, especially in the field of neuroscience.

This is due to High tissue contrast provided by this technology, making it not only extremely sensitive in Detecting structural alterations that effect on The central nervous system, but also in its description. But in addition to structural information, magnetic resonance imaging using advanced technologies allows to obtain Circulatory, metabolic and functional information to the central nervous system, making it The most important imaging techniques in the field of neuroscience For both clinical practice and research.

What advances does Bayer provide with regard to imaging in neuroradiology?

Bayer is currently developing a file New paramagnetic contrast medium It contains gadolinium with a large ring structure and high relaxation. These properties give this contrast media high patient safety and greater diagnostic efficacy. Once clinical trials are completed and approved by regulatory agencies, these new contrast media can be used in clinical practice with the consequent benefit to patients.


“New paramagnetic contrast agents provide high safety and greater diagnostic efficacy”



In diagnosing brain tumors, what distinguishes Bayer’s contrast medium from others?

The Contrast medium containing gadolinium Who is Bayer owner More relaxation Among those with a large annular structure. Currently, in EU countries, contrast media with a large toroidal structure can only be used in MRI studies of the central nervous system, since they are many More stable than those with linear structure Thus, they stimulate less deposition of gadolinium in various tissues such as brain and bone.

Although tissue deposits of gadolinium did not show clinical consequences, it seems reasonable to reduce them to a minimum. precautionary measure Against possible long-term side effects.

What benefits does Bayer contrast medium bring in MRI for the diagnosis of brain tumors?

As for its benefits, it has more relaxing contrast medium Bayer gadoliniumwith respect to other contrast media with a large toroidal structure, makes it more effective in paramagnetic effect In the detection of various pests such as brain tumors.

According to recent studies, they suggest that, together with a contrast medium, using some special sequences such as SPACE and VIBE, this makes it possible to obtain additional information from MRI of brain tumors. How does the combination of the two help in the diagnosis of brain tumors?

Certain MR sequences were obtained in combination with administration of gadolinium-containing contrast media, such as space and livelinessand he Volumetric acquisition (3D), implemented incrementally into clinical routine.

These sequences improve, compared to other T1-weighted 3D sequences such as MPRAGE (often used to detect contrast-enhanced lesions), Detection of tumor lesions such as gliomas and Brain metastases.



“We radiologists will continue to play a key role in obtaining and interpreting radiological studies”



What kind of additional information can you provide?

As for the kind of information these special sequences can provide, VIBE sequences, Obtained with contrast management, allow to obtain perfusion maps By analyzing the permeability of the blood-brain barrier that helps characterize the lesions and evaluate the effectiveness of treatments.

What does AI contribute or can contribute to this type of radiation technology?

The Artificial intelligence (AI) will play a very important role in analyzing Radiological studies. In this sense, the use of algorithms based on “machine learning’ that allow Automatic detection of infection and appreciation, it will be of great help to our work, by Improved sensitivity and reproducibility We have it with simple visual analysis of radiographs, which will eventually improve Diagnostic efficacy.

Also, artificial intelligence, from the analysis of the data provided by the radiographs, will contribute to the creation of predictive models which may have an effect on patient management.

In this sense, what will AI mean for the future of radiology?

In terms of what AI will mean for the future of specialization, The role of the radiologist Not in danger at all, since what Provided by AI is basically a kind of value-added information (not a substitute) for that which we obtain through simple visual analysis, and this makes some of the mechanical tasks we perform in clinical practice more efficient.

In any case, we radiologists will continue to play a fundamental role in Obtaining and interpreting radiological studiesas well as in the necessary validation of the results provided by various artificial intelligence techniques that are already beginning to be used in clinical practice.

Although it may contain statements, statements, or notes from health institutions or professionals, the information in medical writing is edited and prepared by journalists. We recommend the reader to consult a health professional for any health-related questions.

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