Does bariatric surgery protect against cancer?

Most cancers were less common in the bariatric surgery group.

One author noted that for other individual cancers, there was a trend or indication towards reducing their risk after surgery. Photo: shutterstock.

A new study provides more evidence that the significant weight loss achieved with bariatric surgery provides long-term protection against cancer.

The study found that obese adults who had bariatric surgery had a 32 percent lower risk of developing obesity. cancer and 48% lower risk of death than cancercompared to their peers who did not undergo surgery.

“The magnitude of the benefit was very large and dose-dependent, with increased weight loss associated with a greater reduction in risk cancerPrincipal investigator Ali Aminian, MD, director of the Cleveland Clinic Institute of Metabolism and Obesity, Cleveland, Ohio, told Medscape Medical News.

The study was published online in the Journal of the American Medical Association and presented at the 82nd Scientific Session of the American Diabetes Association (ADA), held in New Orleans.

Best guide so far

“We know obesity is closely related to different types of cancerBut we didn’t know if losing a significant amount of weight could significantly reduce your risk cancerAminian explained.

The SPLENDID study included 30,318 obese adults (mean age, 46 years, 77% women, mean BMI, 45 kg/m2).

5,053 patients who underwent gastric bypass (66%) or sleeve gastrectomy (34%) (1:5) were compared with 25,265 patients who did not undergo bariatric surgery (the non-surgical control group).

In 10 years, patients who had bariatric surgery lost 60 pounds (27.5 kg) compared to just 6 pounds (2.7 kg) for their peers who did not have surgery, a difference of 19,2%.

During a median follow-up of 6.1 years, 96 patients in the bariatric surgery group and 780 patients in the non-surgical control group developed disease. cancer Obesity-related (incidence rate of 3.0 vs 4.6 events per 1000 person-years).

At 10 years, the cumulative incidence rate cancer Associated with obesity was significantly lower in the bariatric surgery group (2.9% vs 4.9%; absolute risk difference 2.0%; 95% CI, 1.2%-2.7%; adjusted hazard ratio). [HR] , 0.68; 95% CI, 0.53 – 0.87; P = 0.002).

most types cancer It was less common in the bariatric surgery group. However, there is a comprehensive analysis of the impact of bariatric surgery on types of cancer An individual.

In fully modified Cox models, the relationship between bariatric surgery and types of cancer People were only important to cancer of endometriosis (adjusted heart rate, 0.47; 95% CI, 0.27 – 0.83).

For other individual cancers, Aminian said, there was “a trend or indication towards reducing their risk after surgery.”

He pointed out that cancer of endometriosis the strongest association with obesity, and that patients who seek bariatric surgery are usually middle-aged obese women.

“So it was not surprising that we had more cases cancer of endometriosis of other types cancer“, He said.

Source consult here.