Clinical trial against amyotrophic lateral sclerosis

Anna Martinez, researcher in the CSIC Medicinal and Biotransformative Chemistry Group.

The Spanish search linked to amyotrophic lateral sclerosis (ELA) is making a full sail and recently Biological Research Center Margherita Salas (CIB-Csic) patented a compound to combat this illness. After achieving great results in animal modelsThe next step you intend to take Anna Martinezresearcher from group Translational medicinal and biological chemistry From CSIC, is to start organizational process to order Phase I clinical trials.

To take the molecule against amyotrophic lateral sclerosis to the clinic, Martinez realizes that without a Strong economic investment can hardly be search tested in Humansso the conversations have already begun with pharmaceutical companies And the spin off Interested in supporting the project. Chemistry states in medical writing That “we have to appreciate Spanish search by ELA worldwide. Spain has competitive searchbut we need to productive sector about these The fruits of our labor stay in Spain.

“We need the productive sector so that the fruits of our labor remain in Spain”

Once financial assistance is obtained, the goal set by Martínez is to identify different stages From stabilization process to create Acceptable Pharmaceutical Formula for a person to take. We must analyze toxicology in two kinds of animalsa rodents and the other that do not be. Thus, the animals will undergo 28 days to follow s 14 More recovery To analyze possible side effects, safety of the respiratory system, central nervous system, etc. These are steps required by the regulator to ensure that the drug will not harm humans.”

Another step that researchers associated with the investigation should take is to start a therapeutic windowwhich is, as Martinez explains, “the creation of a edge between dose What is this effective In the animal model, which we already have, and dose let her come toxicfor later treatment.”

It can take up to 15 years for a definitive drug against ALS

Project start gun linked to file receipt necessary investmentand once this is achieved, Martinez calculates that “the organizational process will take 2 years to complete How long does it take for the authorities to approve Phase I clinical trials. will study drug behavior In healthy volunteers, little by little we will increase the dose. At best it will take between 5 and 7 years at start The second phase With patients, until the compound becomes A A real drug against ALS may take from 12 to 15 years old“.

“For the compound to become a real drug against amyotrophic lateral sclerosis, it could take 12 to 15 years”

The minimum investment required to promote a CSIC project is Three million euroswhich is an amount that, in the researcher’s words, “must be managed from private institutions. We put science into value to be able to Transfer it to the productive sectors The community supported us. Companies must implement the developments to commercialize them.”

The molecule and its efficacy in neurodegenerative diseases

Moreover, the investigation hopes that the compound has been patented and awarded as the best invention for Spanish Patent and Trademark Office (OEPM) can be used for others Neurological diseases. “In these diseases that exist TDP-43 . proteinThe medicine can return to its normal function. We’re looking at it in models of Alzheimer’s disease. We recently investigated the importance of this protein in certain types of dementia, and the potential for further research to do so in animal modelsMartinez concludes.

Although it may contain statements, statements, or notes from health institutions or professionals, the information in medical writing is edited and prepared by journalists. We recommend the reader to consult a health professional with any health-related questions.

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