Tissue bioprinter creates 3D ears to implant in humans, future of regenerative medicine?

It is now possible to “print” and implant live cartilage; In the future, perhaps bones and even organs, experts estimate.

AuriNovo, of medical company 3DBio Therapeutics, which is in phase 1/2A clinical trials, presents itself as a solution to this and, if successful, could begin a series of further studies to print different types of tissue on a tissue-based basis. Engineering and Regenerative Medicine.

The first live-tissue-printed implant was successfully performed in a Mexican patient with micro eardrum in March, and the review will continue for years to come, according to a 3DBio Therapeutics press release.

This procedure is not surgical, but is done on an outpatient basis. Chondrocytes, that is, chondrocytes, are first removed from the affected ear of the patient; These cells are then cultured in a special environment for reproduction and then mixed with collagen ink also developed by a company called ColVivo; This ‘mass’ is then shaped by the 3D bioprinter until it takes the shape of a typical ear within 10 minutes and is finally implanted into the patient.

Aurinovo and the bioprinter are part of developments in the emerging fields of tissue engineering and regenerative medicine.

Tissue engineering refers to the practice of combining scaffolds (cellular supporting structures) with bioactive cells and molecules to create functional tissues that greatly reduce the chances of the body rejecting them after transplantation.

On the other hand, regenerative medicine is based on tissue engineering and is more of a paradigm shift in medical treatment. This consists of using the human body’s systems to heal themselves and rebuild tissues, explains the National Institute of Biomedical Imaging and Bioengineering portal.

“The 3D ear implant is thus a proof of concept for evaluating biocompatibility, shape matching, and shape retention in living people,” says James Iatrides, who directs the Laboratory for Bioengineering of the Spine at the College of Medicine. Times (TNYT).

In Mexico, 7 out of every 10,000 children are born with microauricle malformation, a congenital deformity of the ear or ears, who have to undergo surgical procedures to reconstruct the pinna using a rib cartilage graft or have to settle in a prosthesis, according to data from the prospectus. Children’s Hospital of Mexico Medical Center for the year 2014.

More than just ears

Other implants are currently being developed in other laboratories within these areas of study, such as the bladder, blood vessels, trachea, disc bones, and even organs such as the heart, lungs, and liver. However, there is a long way to go before it is taken to humans.

3DBio Therapeutics aims to achieve this one day, learning first from the results of AuriNovo, moving each time from “just aesthetic” to functional: “We believe the microtia clinical trial can provide us with not only strong evidence about the In the statement: “The value of this innovative product and the positive impact it can have on patients with small ears, but much more than that.”

They will then advance with other cartilages such as the nose, bones of the spine and finally even organs, Cohen added, to either rebuild or rehabilitate not only congenital malformations, but also trauma, degeneration or resection due to cancer.

While “just going from ear to disc is a big leap, it’s much more realistic if you have an ear,” Dr. Feinberg at Carnegie Mellon told TNYT.

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